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目的探讨胺碘酮对正常和缺血心脏心室复极及复极离散度的影响，给临床研究提供实验依据。方法采用同步记录心室外膜多个部位单相动作电位的方法，观察家兔正常心脏（正常组）和急性缺血心脏（缺血组）静注胺碘酮前后单相动作电位时程（ＭＡＰＤ９０）和单相动作电位离散度（ＭＡＰＤｄ）的变化。结果正常组用药后左室前壁、左室心尖部和左室侧壁ＭＡＰＤ９０均显著延长（Ｐ均＜０００１），ＭＡＰＤｄ无显著变化（Ｐ＞００５）。缺血组用药后缺血区（左室前壁及左室心尖部）和非缺血区（左室侧壁）ＭＡＰＤ９０均显著延长（Ｐ均＜０００１），但ＭＡＰＤｄ明显减小（Ｐ＜００１）。结论胺碘酮可延长正常和缺血心脏心室复极，对正常心脏复极离散度无影响，但对缺血心脏可使其复极离散度缩小。
Objective To investigate the effect of amiodarone on ventricular repolarization and repolarization dispersion in normal and ischemic heart and to provide experimental evidence for clinical research. Methods The monophasic action potentials were recorded synchronously at multiple sites of ventricular epicardium in rabbits. The changes of monophasic action potentials (MAPD90) before and after intravenous amiodarone in rabbits with normal heart (normal group) and acute ischemic heart (ischemic group) ) And single-phase action potential dispersion (MAPDd) changes. Results The MAPD90 in the left ventricular anterior wall, left ventricular apex and left ventricular wall were significantly prolonged in the normal group (all P <0001), but there was no significant change in the MAPDd (P> 0.05). The MAPD90 in the ischemic area (anterior wall of left ventricle and left ventricle) and non-ischemic area (left ventricular wall) in ischemic group were significantly prolonged (P <0001), but MAPDd was significantly decreased <001). Conclusions Amiodarone can prolong the ventricular repolarization in normal and ischemic heart, and has no effect on the normal heart repolarization dispersion. However, it can reduce the repolarization dispersion in ischemic heart.