论文部分内容阅读
目的 探讨急性白血病 (AL)患者血脂变化的临床意义。方法 用酶学法动态检测 6 8例AL患者化疗前、完全缓解期的空腹晨血血清总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇 (HDL C)、甘油三酯 (TG)、载脂蛋白A1(apoA1)和载脂蛋白B(apoB)。结果 化疗前组TC、LDL C、HDL C、APOA1、APOB比对照组和完全缓解组明显降低 (P <0 0 5 ) ,而TG则比对照组和完全缓解组明显升高 (P <0 0 5 )。完全缓解组 6项指标与对照组相比无差异、若复发则再次出现上述改变。急性淋巴细胞白血病 (ALL)与急性非淋巴细胞白血病(ANLL)血脂水平无差别。外周血白细胞≥ 2 0× 10 9/L组较 <2 0× 10 9/L组血脂改变更显著。结论 动态监测AL的血脂水平有助于判断其疗效和预后。
Objective To investigate the clinical significance of blood lipid changes in patients with acute leukemia (AL). Methods Enzyme method was used to detect the levels of fasting morning serum total cholesterol (TC), low density lipoprotein cholesterol (LDL C), high density lipoprotein cholesterol (HDL C), glycerol Triester (TG), apolipoprotein A1 (apoAl) and apolipoprotein B (apoB). Results The levels of TC, LDL C, HDL C, APOA1 and APOB in the patients before chemotherapy were significantly lower than those in the control group and the complete remission group (P <0 05), while those in the TG group were significantly higher than those in the control group and the complete remission group 5). The complete remission group of six indicators no difference compared with the control group, if recurrence then again the above changes. There was no difference in serum lipid levels between acute lymphoblastic leukemia (ALL) and acute non-lymphocytic leukemia (ANLL). The peripheral blood leucocytes more than 2 0 × 10 9 / L group than <2 0 × 10 9 / L group of lipid changes more significant. Conclusion The dynamic monitoring of AL in blood lipid level is helpful to judge its curative effect and prognosis.