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自1960年以来,由Eltor弧菌引起了七次世界霍乱,付霍乱大流行,从东南亚开始,继之波及到欧洲,拉美非等共约70多个国家。因此,掀起了对本病研究的高潮。现在已经确认,引起霍乱,付霍乱特有的腹泻物质是霍乱菌产生的外毒素。关于此毒素的研究,目前正处于日新月异状态,现在已能精制成高度纯品。它对阐明霍乱,付霍乱发病机理,提供了报为重要的物质基础。环磷酸腺苷(cAMP)的发现历史,只有十多年,它在细胞内通过对酶活性的影响,发挥强大的生理效应,起着调节血糖的作用,早为人们所了解。但据最近研究表明,cAMP的作用,远远超出激素传递物的范畴,它对霍乱菌毒素有着和某些激素相姒的反应机制,在霍乱的发病上起着极为关键的作用,已经引起人们的注意。本文拟以霍乱菌外毒素为中心,阐述其与cAMP在霍乱、付霍乱发病上的相关性。
Since 1960, Vibrio Eltor has caused seven world cholera and cholera epidemic, starting from Southeast Asia, followed by Europe and Latin America and Africa in about 70 countries. Therefore, setting off the climax of the study of this disease. It has now been confirmed that the diarrhea that causes cholera and cholera is an exotoxin produced by cholera bacteria. The study of this toxin, which is currently in a state of rapid change, has now been refined to a high degree of purity. It provides an important material basis for elucidating the pathogenesis of cholera and cholera. The discovery of cyclic adenosine monophosphate (cAMP) has a history of just over a decade. It plays a powerful role in the regulation of blood glucose by exerting powerful physiological effects on the activity of enzymes in cells, and it has long been understood by people. However, recent studies have shown that the role of cAMP far beyond the scope of hormone delivery, it has a certain mechanism of response to certain hormone hormones and cholera toxin play a crucial role in the pathogenesis of cholera has caused people Attention. This article intends to cholera exotoxin as the center, elaborated its cAMP in cholera, cholera associated with the incidence.