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根据药代动力学原理,采用荧光偏振免疫法(FPIA)检测不同时间内豚鼠外淋巴中庆大霉素的浓度,了解其蓄积的情况。结果表明:(1)外淋巴内的药物浓度随庆大霉素用药量的增加而上升,基本上呈线性关系:(2)在注射7d的一组动物,停药72h仍能测到药物,其浓度接近血清最低有效浓度,达1.3±0.95μg/ml,提示内耳对药物排泄十分缓慢,确实存在外淋巴对庆大霉素的明显蓄积:(3)前述事实表明,即使已停药数日,药物的耳毒作用仍在继续,从而解释了临床上有些病人在停药后仍出现耳毒症状或症状加剧的问题。
According to the principle of pharmacokinetics, fluorescence polarization immunoassay (FPIA) was used to detect the concentration of gentamicin in the perilymph of guinea pigs in different time to understand its accumulation. The results showed that: (1) The concentration of drug in perilymph increased with the increase of gentamicin dose, which was basically linear. (2) In the group of 7d, Its concentration close to the serum minimum effective concentration of 1.3 ± 0.95μg / ml, suggesting that the inner ear excretion of drugs is very slow, there is indeed a significant accumulation of the outer lymph of gentamicin: (3) The above facts show that, even if the drug has been discontinued for several days , The ototoxicity of the drug is still continuing, thus explaining the problem that some patients still have ototoxicity or aggravating their symptoms after stopping the medicine.