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目的 :检测乳腺癌患者血清中CYFRA2 1 1水平 ,探讨其在乳腺癌的术前诊断和术后随访监测中的应用价值。方法 :采用放免法测定 34例乳腺良性疾病患者术前、4 7例乳腺癌患者术前和术后 4周及 56例乳腺癌术后随访患者的血清CYFRA2 1 1水平 ,进行对照分析。结果 :乳腺良性疾病无 1例阳性 ;乳腺癌术前阳性率仅 2 1% ,但两者血清CYFRA2 1 1水平有明显差异 ;4 7例乳腺癌患者手术前与术后 4周血清CYFRA2 1 1水平相比有显著差异 ;56例乳腺癌患者术后随访 8例转移复发者中 6例阳性 ,无转移复发者均阴性 ,转移复发者血清CYFRA2 1 1水平较无转移复发者明显增高 ,两者相比差异有极显著性。结论 :血清CYFRA2 1 1检测对乳腺癌特异性高 ,但对乳腺癌术前诊断价值不大 ,对乳腺癌转移复发的监测有非常重要意义。
Objective : To detect the serum level of CYFRA211 in breast cancer patients and explore its value in the preoperative diagnosis and follow-up monitoring of breast cancer. Methods : Serum CYFRA211 level in 34 patients with benign breast disease, 47 preoperative and 4 postoperative weeks, and 56 breast cancer follow-ups were measured by radioimmunoassay. Results: There was no positive benign breast disease; the preoperative positive rate of breast cancer was only 21%, but there was a significant difference in serum CYFRA211 levels; 47 cases of breast cancer patients before surgery and 4 weeks after surgery serum CYFRA2 1 1 There was a significant difference between the levels; 56 cases of breast cancer patients were followed up in 8 cases of metastasis recurrence in 6 cases were positive, no metastasis recurrence were negative, metastasis and recurrence of serum CYFRA211 level was significantly higher than those without metastasis recurrence, both The difference is extremely significant compared to the difference. Conclusion: The serum CYFRA211 has a high specificity for breast cancer, but it has little value in the preoperative diagnosis of breast cancer. It is very important to monitor the metastasis and recurrence of breast cancer.