论文部分内容阅读
目的评价白眉蛇毒血凝酶联合复方戊酸雌二醇片治疗绝经过渡期功能失调性子宫出血的疗效,并观察其对患者血清促卵泡生成素(FSH)、黄体生成素(LH)及雌激素(E_2)水平的影响。方法选取2014年1-9月该院收治的绝经过渡期功能失调性子宫出血患者100例为研究对象,随机分为观察组与对照组,各50例。对照组采用复方戊酸雌二醇片治疗。观察组在对照组治疗基础上联合白眉蛇毒血凝酶肌肉注射治疗。结果观察组控制出血时间(22.73±11.19)h低于对照组(34.45±12.51)h,差异有统计学意义(P<0.01);观察组完全止血时间(53.91±21.62)h低于对照组(75.42±23.39)h,差异有统计学意义(P<0.01)。观察组总有效率(92.00%)高于对照组(74.00%),差异有统计学意义(P<0.01)。治疗后,观察组患者血清FSH、LH及E_2水平分别为(26.85±8.97)U·L~(-1)、(23.15±8.36)U·L~(-1)、(129.84±46.75)pmol·L~(-1),均低于对照组(52.13±9.05)U·L~(-1)、(38.42±7.95)U·L~(-1)、(325.76±51.42)pmol·L~(-1),差异均有统计学意义(P<0.01)。治疗期间,两组患者均未出现肝、肾功能及其他影响治疗的严重不良反应。结论白眉蛇毒血凝酶联合复方戊酸雌二醇片能够显著控制绝经过渡期功能失调性子宫出血患者的出血时间,缩短阴道流血时间,并能明显改善绝经过渡期功能失调性子宫出血患者的血清FSH、LH、E_2水平。
Objective To evaluate the curative effect of white eyebrow venom hemagglutinin combined with compound valerate valerate on dysfunctional uterine bleeding in menopausal transitional period and to observe its effect on serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and estrogen (E_2) level of the impact. Methods A total of 100 patients with dysfunctional uterine bleeding in the menopausal transitional period admitted from January to September in 2014 were enrolled in this study. The patients were randomly divided into observation group and control group, with 50 cases each. The control group was treated with compound valerate valerate. The observation group was treated with intramuscular injection of Bai Mei snake venom hemagglutinin on the basis of the control group. Results The bleeding time (22.73 ± 11.19) h in observation group was lower than that in control group (34.45 ± 12.51) h, the difference was statistically significant (P <0.01); the complete bleeding time in observation group was lower than that in control group (53.91 ± 21.62) h 75.42 ± 23.39) h, the difference was statistically significant (P <0.01). The total effective rate (92.00%) in the observation group was higher than that in the control group (74.00%), the difference was statistically significant (P <0.01). After treatment, the levels of serum FSH, LH and E_2 in the observation group were (26.85 ± 8.97) U · L -1, (23.15 ± 8.36) U · L -1, (129.84 ± 46.75) pmol · L ~ (-1) were lower than that of control group (52.13 ± 9.05) U · L ~ (-1), (38.42 ± 7.95) U · L ~ (-1), (325.76 ± 51.42) pmol·L ~ -1), the differences were statistically significant (P <0.01). During treatment, no adverse effects of liver and kidney function and other adverse reactions were observed in both groups. Conclusions White-browed snake venom hemagglutinin combined with compound valerate valerate can significantly control the bleeding time, shorten the vaginal bleeding time and improve the serum of dysfunctional uterine bleeding patients during menopause transitional dysfunctional uterine bleeding FSH, LH, E_2 level.