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重组干扰素γ(IFN-γ)在体外能选择性有效地抑制正常人皮肤成纤维细胞和硬皮病成纤维细胞产生胶原,并对体液免疫和细胞介导免疫具有免疫调节活性。本文旨在评价重组 IFN-γ对系统性硬化的临床疗效。
Recombinant IFN-γ can selectively and effectively inhibit the collagen production in normal human dermal fibroblasts and scleroderma fibroblasts in vitro and has immunomodulatory activity on humoral and cell-mediated immunity. This article aims to evaluate the clinical efficacy of recombinant IFN-γ on systemic sclerosis.