论文部分内容阅读
制备和表征肿瘤热疗用羧基化PEG修饰的Fe_3O_4磁流体。化学共沉淀方法制备四氧化三铁磁性纳米颗粒,然后用羧基化PEG修饰;用邻二氮菲显色法测定磁流体中铁的含量;沉降方法考察了制备的磁流体的稳定性;通过X射线衍射、透射电子显微镜、红外和振动样品磁强计对制备的磁流体进行表征;测定了磁流体在交变磁场作用下的热效应。羧基化PEG修饰的磁流体稳定性明显优于未修饰的;红外图谱和X衍射图谱证明所制备的磁流体样品由Fe_3O_4组成;透射电镜照片显示磁性粒子分散良好;经X衍射数据计算得磁性粒子的粒径约为5 nm;羧基化PEG修饰磁流体的饱和磁化强度和剩余磁化强度分别为47.01和3.41 emu/g。矫顽力为6.7 Oe;磁流体的特征吸收率为63.0 W/g[Fe]。羧基化PEG修饰的Fe_3O_4磁流体有望用于肿瘤热疗。
Preparation and characterization of tumor hyperthermia with carboxylated PEG modified Fe_3O_4 magnetic fluid. Chemical coprecipitation method to prepare ferroferric oxide magnetic nanoparticles and then modified with carboxylated PEG; the content of iron in the magnetic fluid was measured by phenanthroline colorimetric method; the stability of the prepared magnetic fluid was investigated by sedimentation method; Diffraction, transmission electron microscopy, infrared and vibrational sample magnetometer were used to characterize the prepared magnetic fluid. The thermal effect of magnetic fluid under the action of alternating magnetic field was measured. The stability of magnetic fluid modified by carboxylated PEG was obviously better than that of unmodified ones. The IR and X-ray diffraction proved that the magnetic fluid samples were composed of Fe_3O_4. The TEM images showed that the magnetic particles were well dispersed. The XRD data showed that the magnetic particles Particle size is about 5 nm. The saturation magnetization and remanent magnetization of carboxylated PEG modified magnetic fluid are 47.01 and 3.41 emu / g, respectively. The coercivity was 6.7 Oe and the characteristic absorption of magnetic fluid was 63.0 W / g [Fe]. Carboxylated PEG-modified Fe3O4 magnetic fluids are expected to be used in tumor hyperthermia.