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除了储存能量的白色脂肪组织(WhitetAdiposetTissue,tWAT),t人类和小型哺乳动物体内也存在着消耗能量的棕色脂肪组织(BrowntAdiposetTissue BAT).tBAT对于小型哺乳动物和人类婴儿的体温维持具有重要作用.棕色脂肪细胞内含有很多小脂滴和丰富的血管、神经和线粒体.棕色脂肪的线粒体通过去偶联反应把ATP转化成热量.近年来的研究结果表明,增加棕色脂肪的数量或者提高棕色脂肪的活性可以抑制高脂饮食诱导的体重增加,改善胰岛素抵抗,治疗肥胖.这说明棕色脂肪很可能是防治肥胖以及相关疾病的强有力的靶器官.本文综述了近年来有关棕色脂肪在改善代谢功能、激活棕色脂肪和米色脂肪的相关因子以及其临床运用等方面的研究进展.
In addition to the energy-storing white adipose tissue (White tAdipose tissue, tWAT), there is energy-consuming brown adipose tissue (Brown TAdipose Tissue BAT) in humans and small mammals. TBAT For small mammals And human infant body temperature maintenance plays an important role in. Brown adipocytes contain many small lipid droplets and rich in blood vessels, nerves and mitochondria. Brown fat mitochondria through the decoupling reaction of ATP into heat .In recent studies have shown that, Increasing the amount of brown fat or increasing the activity of brown fat can inhibit the weight gain induced by high-fat diet, improve insulin resistance and treat obesity, indicating that brown fat may be a powerful target organ for the prevention and treatment of obesity and related diseases.This article reviews In recent years, the research progress on the related factors of brown fat in improving metabolic function, activating brown fat and beige fat and its clinical application has been made.