论文部分内容阅读
目的分析广东省艾滋病病毒(HIV)感染母亲所生新生儿,发生低出生体重的影响因素。方法提取2007年1月至2015年6月,广东省免费预防艾滋病母婴传播项目登记的1 365例HIV感染母亲及其所生活产新生儿的个案调查数据,采用多因素Logistic回归分析。结果HIV感染母亲所生的1 365名新生儿中,13.11%(179人)的出生体重<2 500g(低出生体重),1.03%(14例)的出生体重<1 500g(极低出生体重)。这些新生儿低出生体重的高危因素有母亲年龄较大[矫正比值比(aOR)=1.05,95%可信区间(CI):1.02~1.08]、流动人口[市内各县区间流动(aOR=1.77,95%CI:1.14~2.75)、省内各市间流动(aOR=2.52,95%CI:1.41~4.48)]、注射吸毒感染HIV(aOR=2.53,95%CI:1.09~5.91)、围产期发生并发症(aOR=2.52,95%CI:1.68~3.79)、孕期服用抗艾滋病病毒药物(aOR=1.84,95%CI:1.24~2.71)、早产[28-32周(aOR=58.01,95%CI:7.07~476.04),33-36周(aOR=4.64,95%CI:2.34~9.21)]、以及女性新生儿(aOR=1.72,95%CI:1.18~2.51)。结论 HIV感染母亲所生新生儿低出生体重的发生受母亲社会经济特征、围产期高危因素和新生儿性别等多因素影响,需要综合评估和干预。
Objective To analyze the influencing factors of low birth weight in infants born to mothers with HIV in Guangdong Province. Methods A total of 1 365 HIV-infected mothers and their newborn infants born from Guangdong Free HIV / AIDS Prevention and Mother-to-Child Transmission Project were collected from January 2007 to June 2015. Multivariate Logistic regression analysis was used. Results Of the 1 365 newborns born to HIV-infected mothers, 13.11% (179) had birth weights <2 500 g (low birth weight), 1.03% (14 cases) birth weight <1500 g (very low birth weight) . The risk factors for low birth weight in these newborns were older mothers (aOR = 1.05, 95% confidence interval (CI): 1.02-1.08), floating population [inter- (AOR = 2.52, 95% CI: 1.41-4.48)], HIV infection by drug abuse (aOR = 2.53, 95% CI: 1.09-5.91) (AOR = 1.84, 95% CI: 1.24-2.71) and preterm birth [28-32 weeks (aOR = 58.01, 95% CI: 7.07-476.04), 33-36 weeks (aOR = 4.64, 95% CI: 2.34-9.21), and female neonates (aOR = 1.72, 95% CI: 1.18-2.51). Conclusion The incidence of low birth weight in neonates born to HIV-infected mothers is affected by multiple factors such as mother’s socioeconomic characteristics, perinatal high risk factors and neonatal sex, and needs comprehensive assessment and intervention.