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目的评价农村地区中老年轻中度原发性高血压患者的短期规范服用依那普利治疗的降压疗效。方法 2008年5月～2009年7月,在安徽省安庆市及江苏省连云港市农村社区,纳入45～75岁的轻中度原发性高血压患者7 716人,均给予依那普利10 mg/d,治疗3周,通过电话和入户随访保障居住在社区的规范服药,观察依那普利的3周降压疗效。结果治疗3周后,安庆男、女性患者收缩压变化值分别为(-17.3±16.9)mmHg、(-18.5±17.6)mmHg;舒张压变化值分别为(-6.8±9.4)mmHg、(-6.7±9.0)mmHg;降压有效率分别为49.3%、49.1%;降压达标率分别为41.0%、43.5%。连云港男、女性患者收缩压变化值分别为(-16.5±16.1)mmHg、(-18.6±16.6)mmHg;舒张压变化值分别为(-7.0±9.9)mmHg、(-6.4±9.4)mmHg;降压有效率分别为51.8%、50.9%;降压达标率分别为39.4%、42.4%。各年龄段均获有效的血压下降,降压有效率和达标率差异无统计学意义。结论在农村社区规范服用依那普利治疗轻中度高血压,可以获得良好的短期降压疗效和比较理想的降压有效率及达标率。
Objective To evaluate the antihypertensive efficacy of enalapril in short-term treatment of middle-aged and elderly patients with mild to moderate essential hypertension in rural areas. Methods From May 2008 to July 2009, 7 716 mild to moderate essential hypertension patients 45 to 75 years old were enrolled in Anqing City, Anhui Province and Lianyungang City, Jiangsu Province. Enalapril 10 mg / d, for 3 weeks. Through the telephone and home visit, the standardized medication for living in the community was guaranteed and the antihypertensive efficacy of enalapril for 3 weeks was observed. Results After 3 weeks of treatment, the changes of systolic blood pressure were (-17.3 ± 16.9) mmHg and (-18.5 ± 17.6) mmHg in male and female patients, respectively. The changes of diastolic blood pressure were (-6.8 ± 9.4) mmHg and ± 9.0) mmHg. The effective rates of blood pressure lowering were 49.3% and 49.1%, respectively. The compliance rates of blood pressure lowering were 41.0% and 43.5% respectively. The change of systolic blood pressure was (-16.5 ± 16.1) mmHg and (-18.6 ± 16.6) mmHg respectively in male and female patients in Lianyungang Hospital, and the change of diastolic blood pressure was (-7.0 ± 9.9) mmHg and (-6.4 ± 9.4) mmHg respectively The effective rates of pressure were 51.8% and 50.9%, respectively. The compliance rates of pressure lowering were 39.4% and 42.4% respectively. All age groups were effective in lowering blood pressure, effective rate of blood pressure and compliance rate was no significant difference. Conclusions In rural areas, taking enalapril for the treatment of mild to moderate hypertension can achieve good short-term antihypertensive effect and an ideal hypotensive efficiency and compliance rate.