螺环氧化吲哚是一类非常重要的核心结构,它存在于大量有生物活性的化合物中.虽然其重要性引起了大量合成化学家的兴趣,但简单有效且对映选择性地构建含多个手性中心的该骨架的方法仍非常有限.近来,α-异硫氰酸酯类化合物被用于通过Aldol或Mannich反应来构建手性的β-羟基或者β-氨基的α-氨基 Spiro epoxides are a very important class of core structures that exist in a large number of biologically active compounds. While their importance has attracted the interest of many synthetic chemists, the simple, efficient and enantioselective construction of The method for this scaffold of several chiral centers is still very limited Recently, α-isothiocyanates have been used to construct chiral β-hydroxy or β-amino α-amino groups by Aldol or Mannich reactions