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近年来,分子靶向药物在治疗肺癌方面取得了一定成效,如维甲酸已被用于治疗多种肿瘤性疾病,其作用机理包括直接诱导肿瘤细胞分化、抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡等。本文采用蓓萨罗丁与顺铂和长春瑞宾联合治疗非小细胞肺癌,并与单纯应用蓓萨罗丁治疗非小细胞肺癌的临床效果进行比较,以分析其选择性抗肿瘤活性及其作用机理。
In recent years, molecular targeted drugs in the treatment of lung cancer has achieved some success, such as retinoic acid has been used to treat a variety of neoplastic diseases, its mechanism of action includes direct induction of tumor cell differentiation, inhibition of tumor cell proliferation, induction of tumor cell apoptosis Wait. In this paper, the combination of bexarotene with cisplatin and vinorelbine in the treatment of non-small cell lung cancer was compared with the simple clinical application of bexarotene in the treatment of non-small cell lung cancer to analyze its selective anti-tumor activity and its role mechanism.