核转录因子κB(NF-κB)是一种重要的转录因子蛋白,广泛存在于机体各种组织细胞中,对多种表达诸如:细胞因子、化学因子、生长因子、细胞黏附分子、抗凋亡蛋白基因的上调起关键作用,并且在多种疾病尤其是癌症的发病机制中发挥重要的作用。本文就NF-κB在炎症促进癌症发生发展中的作用以及在癌症治疗中的可行性作一综述。 Nuclear factor kappa B (NF-κB) is an important transcription factor protein widely present in various tissues of the body. It expresses a variety of proteins such as cytokines, chemokines, growth factors, cell adhesion molecules, anti-apoptotic Upregulation of protein genes plays a key role and plays an important role in the pathogenesis of various diseases, especially cancer. This review summarizes the role of NF-κB in the development of inflammation-promoting cancer and its feasibility in cancer therapy.