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随着应用种类繁多的药物,药物诱发的肾脏副反应也日愈增多,除较常见的肾中毒性(例如环孢酶素A和氨基甙类药物)和功能性副作用(例如非水杨酸抗风湿药、NSAR和血管紧张素转换抑制酶)外,药物对产生免疫原性间质性肾炎(AIN)起着重要作用。急性肾小管间质性肾炎组织学可见肾间质浸润、间质水肿和肾小管损伤。服用药物距离发病的问期有很大的差异,再次暴露药物可以复发,故应避免再次用药。仅根据临床诊断并不可靠,而且,因摄入多种药物可增加诊断的困难。
With the wide variety of drugs used, drug-induced renal side effects are also increasing, with the exception of the more common renal toxicities (such as cyclosporin A and aminoglycosides) and functional side effects (such as non-salicylate Rheumatoid, NSAR and angiotensin-converting inhibitor), drugs play an important role in the production of immunogenic interstitial nephritis (AIN). Acute tubulointerstitial nephritis histology showed renal interstitial infiltration, interstitial edema and renal tubular damage. Taking drugs from the onset of questioning period is very different, once again exposed the drug can be relapsed, it should avoid re-medication. Based on clinical diagnosis is not reliable, but also due to the intake of multiple drugs can increase the difficulty of diagnosis.