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目的:探讨5-羟色胺(5-HT)在妊高征发病中的作用。方法:采用高效液相色谱-电化学检测法检测20例正常孕妇及40例妊高征患者血浆及血小板中5-HT浓度及血浆中5-羟吲哚乙酸浓度。结果:妊高征患者血浆中5-HT浓度明显高于正常妊娠(P<001),而且病情越重,血浆中5-HT含量越高。而血小板中5-HT浓度和血浆中5-羟吲哚乙酸(5-HIAA)浓度在正常妊娠和妊高征患者无明显变化(P>005)。结论:血小板释放5-HT异常增多,可能是造成妊高征患者血浆中5-HT浓度增高的主要原因。异常增高的5-HT与妊高征一系列病理改变有密切关系
Objective: To investigate the role of 5-hydroxytryptamine (5-HT) in the pathogenesis of PIH. Methods: The concentrations of 5-HT and 5-hydroxyindole-acetic acid in plasma and platelets of 20 normal pregnant women and 40 cases of pregnancy-induced hypertension were detected by high performance liquid chromatography-electrochemical detection. Results: The plasma 5-HT concentration in patients with PIH was significantly higher than that in normal pregnancy (P <001), and the more serious the disease, the higher the content of 5-HT in plasma. The 5-HT concentration in platelets and plasma 5-HIAA concentration in normal pregnancy and pregnancy-induced hypertension in patients with no significant change (P> 0 05). Conclusion: The abnormal increase of platelet release of 5-HT may be the main reason for the increase of 5-HT concentration in the plasma of patients with PIH. Abnormally elevated 5-HT and PIH a series of pathological changes are closely related