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目的:探讨高危型人乳头状瘤病毒感染者中血清硒、铜及叶酸含量的变化情况.方法:用原子吸收光谱法,检测南疆维吾尔族已婚女性217例人乳头状瘤病毒感染者(病例组)及106例HPV阴性者(对照组)血清中的硒、叶酸及铜含量.统计学方案采用logistic回归t检验.结果:HPV感染者血清中的硒、叶酸含量较非感染者低(P<0.05).血清中铜含量的检测值于两组之间无统计学差异(P>0.05).结论:南疆维吾尔族女性人乳头状瘤病毒感染的发生与缺硒和叶酸的缺乏有关,对人乳头状瘤病毒感染者适当地补充人体必需的微量元素可能是治疗HPV持续感染的一种合理有效的治疗手段.
Objective: To investigate the changes of serum selenium, copper and folic acid in high risk human papillomavirus (HPV) infection.Methods: 217 cases of human papillomavirus infection in married Uygur women in South Xinjiang Uygur Autonomous Region were detected by atomic absorption spectrometry Case group) and 106 cases of HPV-negative (control group) .Conclusion: The serum level of selenium and folic acid in HPV-infected patients is lower than that of non-infected patients (P0.05) .Conclusion: The incidence of Uyghur female human papillomavirus infection in South Xinjiang is related to the deficiency of selenium and folic acid , Proper supplementation of human essential microelements for human papillomavirus infection may be a reasonable and effective treatment for persistent HPV infection.