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目的观察以温敏凝胶为光敏剂载体的5-氨基酮戊酸光动力疗法(ALA-PDT)治疗尖锐湿疣的疗效及安全性。方法 150例尖锐湿疣患者随机分为3组:即温敏凝胶组、灭菌用水组和基质霜组,每组各50例。3组分别采用以温敏凝胶、灭菌用水及基质霜为光敏剂载体的5-氨基酮戊酸光动力疗法治疗尖锐湿疣,每7～10天治疗1次,第4次治疗后3个月时判定疗效。结果温敏凝胶组、灭菌用水组和基质霜组的完全缓解率分别为84.00%,60.00%和64.00%;复发率分别为9.50%,30.00%和28.10%,温敏凝胶组疗效均优于其他两组,且复发率低于其他两组,差异均有统计学意义(P均<0.05)。且3组不良反应差异无统计学意义。结论以温敏凝胶为光敏剂载体的光动力疗法治疗尖锐湿疣的疗效明显优于以注射用水及基质霜为载体的光动力疗法,但3组均有较好的安全性。
Objective To observe the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) with thermo-sensitive gel as photosensitizer carrier in the treatment of condyloma acuminatum. Methods 150 patients with condyloma acuminatum were randomly divided into three groups: the temperature-sensitive gel group, sterile water group and matrix cream group, 50 cases in each group. 3 groups were treated with 5-aminolevulinic acid photodynamic therapy with temperature-sensitive gel, sterilized water and matrix cream as photosensitizer vehicle for treatment of condyloma acuminatum, once every 7 to 10 days and 3 months after the fourth treatment Determine the efficacy. Results The complete remission rates of the thermo-sensitive gel group, sterile water group and matrix cream group were 84.00%, 60.00% and 64.00%, respectively. The recurrence rates were 9.50%, 30.00% and 28.10% Group, and the recurrence rate was lower than the other two groups, the differences were statistically significant (P all <0.05). There was no significant difference between the three groups in adverse reactions. Conclusion Photodynamic therapy with temperature-sensitive gel as photosensitizer is superior to photodynamic therapy using water and matrix cream as carrier for the treatment of condyloma acuminatum, but all three groups have good safety.