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目的 :探讨前哨淋巴结 (sentinellymphnode ,SLN)活检术在非小细胞肺癌 (non smallcelllungcancer ,NSCLC)诊断与分期中的作用和应用可行性。方法 :研究对象共 12例 (男性 2例 ,女性 10例 ,平均年龄 6 8.4岁 ) ,临床肿瘤分期为I～II期。术中将放射性示踪剂99锝硫胶体 (99Tcmsulfurcolloid ,99TcmSC ) 2ml分别等量注射于肿瘤边缘 4个象限 ,总剂量 2mCi。运用手持式γ射线探测扫描仪对研究对象的SLN进行探测扫描并摘取 ,然后均常规行肺门、纵隔淋巴结清扫术 ,标本送常规HE染色病理及免疫组化检查。结果 :12例中均检出SLN ,共 19枚 ;阳性 7例 ,11枚 ,阳性检出率 5 8.3% ,假阴性率 2 0 %。结论 :SLN活检术在寻找早期转移可能淋巴结方面具有较大临床价值。
Objective: To investigate the role and feasibility of sentinellymphnode (SLN) biopsy in the diagnosis and staging of non small cell lung cancer (NSCLC). Methods: A total of 12 subjects (2 males and 10 females with an average age of 6 8.4 years) were included in the study. The clinical staging was stage I-II. Intraoperative radioactive tracer 99Tcmsulfurcolloid (99TcmSC) 2ml were injected equally in the tumor quadrant 4 quadrants, the total dose of 2mCi. The hand-held gamma ray scanning scanner was used to scan and extract the SLN of the study subjects. Histopathological and mediastinal lymph node dissections were performed routinely. The specimens were examined by routine HE staining and immunohistochemistry. Results: SLN was detected in all 12 cases, of which 19 were positive, 7 were positive, 11 were positive, the positive rate was 53.3% and the false negative rate was 20%. Conclusion: SLN biopsy has great clinical value in searching for possible metastasis of early lymph nodes.