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本文选择慢性开角型青光眼成年患者20人,一只眼用下述制剂中的二种,分别进行治疗:安慰剂;0.1％,0.25％,0.5％,1.0％噻吗心安眼水。二次治疗间隔一周。另一只眼不治疗,作为对照。用双盲试验进行研究。观察眼压的时间为治疗前,治疗(点一滴药)后2,4,8,12,24,26,28小时。试验证明:各种浓度的噻吗心安均能使眼压显著下降。治疗后2小时眼压下降明显,并持续到试验结束。0.5％和1.0％,0.1％和0.25％噻吗心安的降眼压作用相似,前两种比后两种作用更强。
In this study, 20 adult patients with chronic open-angle glaucoma were selected. One eye was treated with two of the following preparations: placebo, and 0.1%, 0.25%, 0.5%, 1.0% timolol eye drops. The second treatment interval of one week. The other eye is not treated, as a control. Study with double-blind trial. Observation of intraocular pressure time before treatment, treatment (point a drop of medicine) after 2,4,8,12,24,26,28 hours. Tests show that: various concentrations of timolol can significantly reduce intraocular pressure. IOP decreased significantly 2 hours after treatment and continued until the end of the experiment. 0.5% and 1.0%, 0.1% and 0.25% timolol reduced intraocular pressure effect similar to the former two than the latter two stronger.