目的　观察植物碱和铂类药物联合化疗方案治疗NSCLC的近期疗效和毒副作用。方法　回顾性总结 5 4例ⅢB～Ⅳ期NSCLC病人施以植物碱和铂类药物化疗的近期疗效和毒性反应。结果　CR 6例 ,PR 2 7例 ,NC 17例 ,PD 4例。总有效率 6 1 11%。主要毒副反应为骨髓抑制和消化道毒性。结论　植物碱和铂类药物联合化疗方案治疗晚期NSCLC的近期疗效可靠 ,毒性反应可以耐受。 Objective To observe the short-term curative effect and side effects of combined treatment of plant alkaloids and platinum drugs in the treatment of NSCLC. Methods Retrospectively summarize the short-term efficacy and toxicity of phytoplankton and platinum-based chemotherapy in 54 patients with stage IIIB-IV NSCLC. Results CR was 6 cases, PR 2 7 cases, NC 17 cases, PD 4 cases. The total efficiency is 6 11%. The main toxicities were myelosuppression and gastrointestinal toxicity. Conclusion The short-term curative effect of the combination of plant alkaloids and platinum drugs in the treatment of advanced NSCLC is reliable and the toxicity can be tolerated.