论文部分内容阅读
我们应用免疫组织化学Ｓ－Ｐ方法．研究了１２５例大肠癌Ｐ５３癌基因产物ＰＡｂ１８０１的表达。１２５例大肠癌中Ｐ５３蛋白的阳性率为４０％（５０／１２５）。Ｐ５３蛋白表达结果与年龄、性别、组织学类型，浆膜浸润情况，肝转移情况及淋巴结转移度无关，故我们认为Ｐ５３蛋白过度表达可能与大肠癌预后及临床病理因素无关。尽管Ｐ５３蛋白过度表达与肿瘤部位无统计学关系，但乙状结肠癌Ｐ５３阳性率（６０％）高于直肠癌（４０％），直肠癌高于升结肠癌（３５．７％），这可能提示左、右侧大肠癌的生物学特性有所不同。
We applied the immunohistochemical S-P method. The expression of P53 oncogene PAb1801 in 125 cases of colorectal cancer was studied. The positive rate of P53 protein in 125 cases of colorectal cancer was 40% (50/125). P53 protein expression and age, gender, histological type, serosal invasion, liver metastases and lymph node metastasis unrelated, so we think P53 protein overexpression may not be related to the prognosis of colorectal cancer and clinicopathological factors. Although P53 overexpression did not correlate with tumor location, the positive rate of P53 in sigmoid colon cancer (60%) was higher than that in rectal cancer (40%) and that in rectal cancer was higher than that in ascending colon (35.7%), suggesting that left The right side of the biological characteristics of colorectal cancer are different.