羟自由基(·OH)是最强的氧化剂之一,并且有细胞毒素,其与某些疾病的发生有着密切的关系。异喹啉生物碱,具有广泛的生理活性,本文选择了五种异喹啉生物碱,进行了清除·OH活性的研究。实验证明它们对·OH有一定的清除作用,其清除率随药物浓度的增加而加大,同时证明它们对·OH的生成速率也有一定的抑制作用。 Hydroxyl radical (· OH) is one of the strongest oxidants, and has cytotoxins, which are closely related to the occurrence of certain diseases. Isoquinoline alkaloids, with a wide range of physiological activity, this paper selected five isoquinoline alkaloids, scavenging · OH activity. Experiments show that they · · OH have some scavenging effect, the clearance rate increased with the increase of drug concentration, at the same time, they also prove · OH generation rate also have a certain inhibitory effect.