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目的探讨黄芪对慢性肾功能不全患者抗氧化酶和一氧化氮(NO)的影响。方法 30例慢性肾功能不全患者,给予洛汀新5～10mg/d口服,共8用,其中15例在后4周服用洛汀新同时静点黄芪30ml/d。用黄嘌呤氧化酶法潮定治疗前后血浆超氧化物歧化酶(SOD)、血清NO水平。结果①慢性肾功能不全患者血清NO低于健康对照组,有显著差异(P<0.05);血浆SOD低于健康对照组,有显著差异(P<0.05)。②黄芪、洛汀新组治疗后血浆SOD水平增高,差异显著(P<0.05)。③治疗后 血清NO水平增高,治疗前后差异显著(P<0.05)。治疗后黄芪、洛汀新组血清NO水平高于洛汀新蛆,有显著差异(P<0.05)。结论黄芪保护慢性肾功能不全患者抗氧化酶活性,增加NO,保护肾脏。
Objective To investigate the effects of astragalus on the antioxidant enzymes and nitric oxide (NO) in patients with chronic renal failure. Methods 30 patients with chronic renal failure were treated with Lotensin 5 ~ 10mg / d orally for a total of 8, including 15 in the next 4 weeks taking Lotensin Astragalus 30ml / d. Using xanthine oxidase method before and after tidal fixations of plasma superoxide dismutase (SOD), serum NO levels. Results ① Serum NO in patients with chronic renal insufficiency was significantly lower than that in healthy controls (P <0.05); plasma SOD was significantly lower than that in healthy controls (P <0.05). ② Astragalus and Lotensin increased plasma SOD level after treatment (P <0.05). ③ After treatment, serum NO levels increased significantly before and after treatment (P <0.05). After treatment Astragalus, Lotensin new serum NO levels higher than the new Lotto Ting, there was a significant difference (P <0.05). Conclusion Astragalus protects the activity of antioxidant enzymes, increases NO and protects kidneys in patients with chronic renal insufficiency.