60年前,有人发现活的瘤细胞能使碳水化合物转化成乳酸.此后许多年,人们假设肿瘤主要依赖糖酵解途径产生大量乳酸,而使细胞内pH(pH_i)偏酸性.在介入性时代,用微电极测定肿瘤pH似乎证实了这一假设,但现在知道这种测定主要反映了pHe,即间液(或细胞外液)的pH(范围在5.5～7.3之间).磁共振分光镜(MRS)可用于活体非侵袭性测定组织pH,并于1983年首次测定了人肿瘤的pH.pH_(MRS)测定是根据~(31)Pi(无机磷信号与内源性 60 years ago, it was discovered that living tumor cells can convert carbohydrates into lactic acid. Since then, it has been hypothesized that for many years, tumors rely mainly on the glycolytic pathway to produce large amounts of lactic acid, which makes the intracellular pH (pH_i) acidic. In the interventional era The use of microelectrodes to determine tumor pH appears to confirm this hypothesis, but it is now known that this measurement mainly reflects pHe, the pH of the interstitial (or extracellular fluid) (ranging from 5.5 to 7.3). Magnetic resonance spectroscopy (MRS) can be used for noninvasive determination of tissue pH in vivo, and the pH of human tumors was first determined in 1983. The pH_(MRS) assay is based on ~(31)Pi (inorganic phosphorous signal and endogenous