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用小鼠的输血模型，探讨输血对局部Ｂ１６黑色素瘤生长的影响。结果发现，同种异品系间的输血，可降低受血鼠的ＮＫ细胞活性和淋巴细胞转化率，并能促进肿瘤的生长，肿瘤的体积及重量均明显高于输生理盐水组，而同种同品系间的输血则无此不良影响。本研究提示，Ｈ─２不相容性输血可促进肿瘤的生长，免疫功能下降可能是输血促进肿瘤生长的重要因素。
The blood transfusion model in mice was used to investigate the effect of blood transfusion on the growth of local B16 melanoma. The results showed that blood transfusion between strains of different species could reduce the NK cell activity and lymphocyte transformation rate of recipient mice and promote tumor growth. The volume and weight of tumors were significantly higher than those of normal saline groups. Blood transfusions between the same strain did not have such adverse effects. This study suggests that H-2 incompatible transfusion can promote tumor growth, and decreased immune function may be an important factor in blood transfusion to promote tumor growth.