近年来认为脑内环核苷酸在癫痫等某些神经疾患中可能起着重要作用。有资料报告,多种因素诱发实验性癫痫可引起脑内环核苷酸含量升高。但这些变化在脑内的具体定位还有待阐明。我们以往的工作观察到用荷苞牡丹碱诱发实验性癫痫可引起大鼠的黑质、苍白球及海马等脑区葡萄糖代谢率明显提高,并伴有脑血流改变。本工作用同样的实验性癫痫模型观察了多个脑区cAMP含量的变化。 In recent years, it has been thought that cyclic nucleotides in the brain may play an important role in certain neurological disorders such as epilepsy. Data have reported that multiple factors that induce experimental epilepsy can cause increased levels of cyclic nucleotides in the brain. However, the specific location of these changes in the brain remains to be elucidated. Our previous work has observed that experimental seizures induced by esmolum can cause a significant increase in glucose metabolism in the substantia nigra, globus pallidus, and hippocampus in rats, accompanied by changes in cerebral blood flow. This work used the same experimental epilepsy model to observe changes in cAMP content in multiple brain regions.