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最近对恶性疟原虫研究的证据提示,氯喹抗性机制与哺乳动物肿瘤细胞多重抗药性表型(MDR)类似,是由一种称为P-糖蛋白的蛋白分子介导的。在恶性疟原虫中,已证明有两种基因编码P-糖蛋白同系物,即pfmdr1和pfmdr2。pfmdr1有几种与抗氯喹表型有关联的等位基因。然而,恶性疟原虫抗氯喹株与敏感株之间的遗传杂交分析表明与编码P-糖蛋白同系物的基因无关。本文概述了氯喹抗性表型与哺乳动物肿瘤细胞MDR表型的一些相似物,探索pfmdr基因的可能作用。
Recent evidence of studies on P. falciparum suggests that the chloroquine resistance mechanism is similar to that of mammalian tumor cell multidrug resistance phenotypes (MDRs) and is mediated by a protein molecule called P-glycoprotein. In P. falciparum, two genes have been identified that encode the P-glycoprotein homologs, pfmdr1 and pfmdr2. pfmdr1 has several alleles associated with the chloroquine-resistant phenotype. However, genetic crosses between P. falciparum resistant strains and susceptible strains showed no association with genes encoding P-glycoprotein homologues. This article outlines some similarities between the chloroquine resistance phenotype and the MDR phenotype of mammalian tumor cells and explores the possible role of the pfmdr gene.