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目的评价三维适形放疗联合卡培他滨治疗局部晚期胰腺癌的疗效。方法47例胰腺癌患者分为卡培他滨+三维适形放疗(综合组,25例)和单纯三维适形放疗(单放组,22例),比较疼痛缓解率、近期疗效及生存率。结果综合组和单放组疼痛缓解率分别为80%和65%,近期有效率分别为76%和59%。综合组1、2年生存率分别为64%、16%,显著高于单放组的45.5%、9.1%(P<0.05)。主要毒副反应为1～2级消化道反应及1～3级血液毒性。结论三维适形放疗联合卡培他滨治疗局部晚期胰腺癌,副反应较轻,能改善患者的生存质量,延长生存期。
Objective To evaluate the efficacy of three-dimensional conformal radiotherapy combined with capecitabine in the treatment of locally advanced pancreatic cancer. Methods Forty-seven patients with pancreatic cancer were divided into capecitabine + three-dimensional conformal radiotherapy (25 cases) and simple three-dimensional conformal radiotherapy (22 cases). The pain relief rate, short-term curative effect and survival rate were compared. Results The pain relief rates of the combined group and the single group were 80% and 65% respectively, and the recent effective rates were 76% and 59% respectively. The 1-year and 2-year survival rates of the integrated group were 64% and 16%, respectively, which were significantly higher than 45.5% and 9.1% (P <0.05) of those in the single group. The main side effects of 1 to 2 gastrointestinal reactions and 1 to 3 hematological toxicity. Conclusion Three-dimensional conformal radiotherapy combined with capecitabine in the treatment of locally advanced pancreatic cancer has less side effects and can improve the quality of life of patients and prolong the survival period.