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目的:建立联苯双酯片溶出度的测定方法。方法:以1%十二烷基硫酸钠为溶剂,转数100r.min-1测定溶出度,采用紫外分光光度法测定溶出量。结果:线性范围为5.192～31.152μg.mL-1(r=0.999 9);平均回收率为100.1%;样品溶出度的均一性良好,在45min累积溶出百分率不低于70%。结论:该方法简便、准确,重复性好,可用于该片剂的溶出度测定。
Objective: To establish a method for the determination of bifendate dissolution. Methods: The dissolution rate was determined by using 1% sodium dodecyl sulfate as solvent and the number of revolutions was 100r.min-1. The dissolution rate was determined by UV spectrophotometry. Results: The linear range was 5.192 ~ 31.152μg.mL-1 (r = 0.999 9). The average recovery was 100.1%. The homogeneity of sample dissolution was good. The cumulative dissolution percentage at 45min was not less than 70%. Conclusion: The method is simple, accurate, reproducible and can be used for the determination of the dissolution of the tablet.