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本文评价了大川芎方多元释药系统(Da Chuanxiong Fang multiunit drug delivery system,DCXFMDDS)体内外释药特点。以已知的有效成分阿魏酸(ferulic acid,FA)与洋川芎内酯I(senkyunolide I,SI)为指标成分,采用HPLC法测定其含量,比较了DCXFMDDS与大川芎片的体外释药特征,以及与大川芎方效应组分(Da Chuanxiong Fang active fraction,DCXFAF)的大鼠体内药动学特征。结果表明,DCXFMDDS中FA在体内外具有明显的缓释作用,而SI在体内外均能快速释药,两种物质体外释药特征及其机制均不相同,但体内吸收程度(以AUC表征)均好于DCXFAF组。DCXFMDDS改变了不同化学成分在体内外释药特征,可能是其起效快、药效好、药效维持时间长的原因之一。
This article evaluates the in vitro and in vivo release characteristics of Da Chuanxiong Fang multiunit drug delivery system (DCXFMDDS). The known effective components of ferulic acid (FA) and senkyunolide I (SI) were determined by HPLC method. The in vitro release characteristics of DCXFMDDS and Dachuanxiong tablets were compared , And in vivo pharmacokinetics in rats with Da Chuanxiong Fang active fraction (DCXFAF). The results showed that the FA in DCXFMDDS had a sustained and sustained release in vitro and in vivo, while SI could release rapidly both in vitro and in vivo. The in vitro release characteristics and mechanism of the two substances were different, but the degree of in vivo absorption (characterized by AUC) All better than the DCXFAF group. DCXFMDDS changes the chemical composition of different release characteristics in vitro and in vivo, which may be one of the reasons for its rapid onset, good efficacy, long-term efficacy.