论文部分内容阅读
目的探讨骨桥蛋白(OPN)在牙周炎防治中的影响和作用。方法以本院2015年6月-2016年6月收治的106例牙周炎患者为观察组,另选同期同一地区100例牙周健康者作对照组,采用酶联免疫吸附(ELISA)试验检测2组对象龈沟液中OPN含量,记录并比较其牙龈指数(GI)、探诊深度(PD)、附着丧失(AL)和牙松动度。结果观察组OPN含量高于对照组,差异有统计学意义(P<0.01);OPN含量与GI、PD、AL和牙松动度呈正相关。结论 OPN是牙周组织炎症进展的重要生物标记,通过自身和外部调节降低口腔中的OPN水平,对于有效防治牙周炎有重要的促进作用。
Objective To investigate the effect of osteopontin (OPN) on prevention and treatment of periodontitis. Methods One hundred and sixty patients with periodontitis treated in our hospital from June 2015 to June 2016 were selected as the observation group and another 100 healthy people in the same area of the same period were selected as the control group. ELISA was used to detect The content of OPN in gingival crevicular fluid of the two groups were recorded and compared with the gingival index (GI), exploration depth (PD), attachment loss (AL) and tooth mobility. Results The content of OPN in the observation group was higher than that in the control group (P <0.01). The content of OPN was positively correlated with the mobility of GI, PD, AL and tooth mobility. Conclusion OPN is an important biomarker of inflammation in periodontal tissues. It can reduce the level of OPN in the oral cavity through its own regulation and external regulation, which plays an important role in the prevention and treatment of periodontitis.