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应用间接ELISA法 ,测定 1 674例经胃镜检查患者的血清幽门螺杆菌 (HP)细胞毒素相关基因A(CagA)抗体 ,探讨HP菌型差异与其致胃十二指肠疾病的关系。结果 :疾病组血清CagA抗体检出率为 4 9.70 % ,高于健康组的38% (P <0 .0 5) ;活动期十二指肠溃疡 (DU)的抗体检出率显著高于活动期胃溃疡 (GU)、胃癌 (GC)和慢性胃炎 (CG)(P <0 .0 1 ) ;活动性炎症的抗体检出率显著高于非活动性炎症 (P <0 .0 1 )。随CG炎症程度加重 ,抗体阳性率呈递增性增加 (P <0 .0 5,P <0 .0 1 ) ;GC及各癌前病变抗CagA检出率与健康组比较无差异。提示 :HP产毒菌感染与胃十二指肠粘膜炎症活动及损伤程度有关
The serum level of Helicobacter pylori (HPA) cytotoxin related gene A (CagA) antibody was determined by indirect ELISA in 1674 patients with gastroscopy. The relationship between the bacterial type and the gastroduodenal disease was explored. Results: The detection rate of serum CagA antibody in the disease group was 4.70%, which was higher than that in the healthy group (P <0.05). The detection rate of antibody in active duodenal ulcer (DU) was significantly higher than that in the activity Gastric ulcer (GU), gastric cancer (GC) and chronic gastritis (CG) (P <0.01). The detection rate of active inflammation was significantly higher than that of inactive inflammation (P <0.01). With the aggravation of inflammation, the positive rate of antibody increased progressively (P <0.05, P <0.01). There was no difference in the detection rate of anti-CagA between GC and precancerous lesions compared with healthy controls. Tip: HP toxin-producing bacterial infection and gastroduodenal mucosal inflammatory activity and degree of injury