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目的 :观察软组织肉瘤患者T淋巴细胞亚群中Th1/Th2的变化 ,为细胞因子免疫治疗提供依据。方法 :应用放射免疫分析法以及酶联免疫分析法检测 10例软组织肉瘤患者及 10例健康志愿者血清中IL 2、IL 4、IL 6、IL 10、IL 12的含量 ,检测外周血单个核细胞培养上清中IL 2、IL 4含量。结果 :软组织肉瘤患者血清及培养上清中IL 2、IL 12减少 ,而IL 10、IL 4、IL 6含量增加。经过植物血凝素刺激的培养淋巴细胞上清液中的IL 4含量显著增加 ,而IL 2显著降低。结论 :软组织肉瘤患者体内存在Th1/Th2平衡失调 ,其中Th1亚群功能抑制 ,Th2亚群功能亢
Objective: To observe the changes of Th1 / Th2 in T lymphocyte subsets in patients with soft tissue sarcoma and to provide basis for cytokine immunotherapy. Methods: Serum levels of IL 2, IL 4, IL 6, IL 10 and IL 12 were detected by radioimmunoassay and enzyme-linked immunosorbent assay in 10 patients with soft tissue sarcoma and 10 healthy volunteers. Peripheral blood mononuclear cells The culture supernatant IL 2, IL 4 content. Results: IL 2 and IL 12 in serum and culture supernatant of patients with soft tissue sarcoma decreased, while the contents of IL 10, IL 4 and IL 6 increased. IL-4 levels in cultured lymphocyte supernatant stimulated by phytohemagglutinin increased significantly, while IL2 was significantly reduced. Conclusion: Th1 / Th2 imbalance exists in patients with soft tissue sarcoma, including Th1 subset inhibition, Th2 subset hyperfunction