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自从1979年发现化学致癌物转化细胞的DNA 具有再转化其它正常细胞的能力以来,对化学致癌物及其代谢与癌基因表达或癌基因结构的改变之间的关系,已成为研究化学致癌机理最富有挑战性的一课题。芳香胺和氨基偶氮染料Cramer 等于1960年注意到,持续给小鼠饲以2-乙酰芴胺一周后,尿中可找到新的代谢产物N-羟基衍生物葡糖苷酸,后者较其母体化合物具有更强的致癌性。N-羟基化合物在体内代谢有氧化和还原两条途径。某些硝基化合物如4-硝基喹啉-1-氧化物可通过还原转变成致
The relationship between chemical carcinogens and their metabolism and the expression of oncogenes or changes in the structure of oncogenes has been the study of the mechanism of chemical carcinogenesis since it was discovered in 1979 that DNA of chemical carcinogens transformed cells has the ability to retransform other normal cells Challenging topics. Aromatic amines and amino azo dyes Cramer et al noted in 1960 that a week after feeding 2-acetofluorene to mice, a new metabolite, the N-hydroxy derivative glucuronide, was found in the urine, which was more potent than its parent Compounds are more carcinogenic. N-hydroxy compounds in the body metabolism of oxidation and reduction of two ways. Certain nitro compounds such as 4-nitroquinoline-1-oxide can be converted by reduction