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肿瘤坏死因子(Tumor Necrosis Factor,TNF)是由Coley和Carswell等人发现的,其可引起肿瘤组织的坏死。近年来发现TNF在体外可抑制白血病细胞的生长,这给白血病的治疗带来新的启发。一、肿瘤坏死因子的产生及生物特性 Coley最先描述了肿瘤病人接受链球菌和沙雷氏菌后,肿瘤可发生坏死的现象,以后证明是由内毒素所致,即G杆菌的细胞壁的脂多糖成分(Lipopolysaccaride,简称LPS)引起肿瘤的坏死。1975年Carswell报告预先接种BCG后再注射内毒素的动物血清中存在一种因子,这种因子可引起小鼠和兔体内的肿瘤出血性坏死,称之为肿瘤坏死因子。有一些实验证据提示巨噬细胞是TNF
Tumor Necrosis Factor (TNF) was discovered by Coley and Carswell et al. and caused tumor tissue necrosis. In recent years, it has been found that TNF can inhibit the growth of leukemia cells in vitro, which brings new inspiration to the treatment of leukemia. First, the production and biological characteristics of tumor necrosis factor Coley first described the tumor patients after receiving Streptococcus and Serratia, the tumor can occur in the phenomenon of necrosis, later proved to be caused by endotoxin, the G cell wall of lipopolysaccharide The component (Lipopolysaccaride, LPS for short) causes tumor necrosis. In 1975, Carswell reported that there was a factor in the serum of animals that had been pre-inoculated with BCG and injected endotoxin. This factor can cause hemorrhagic necrosis of tumors in mice and rabbits. It is called tumor necrosis factor. There is some experimental evidence suggesting that macrophages are TNF