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复方庆大霉素针是硫酸庆大霉素和甲氧苄氨嘧啶(TMP)的复合制剂。处方:硫酸庆大霉素1500万单位,TMP 109,无水亚硫酸钠2g,丙二醇300ml,注射用水适量,全量制成1000m1。该注射液中TMP的含量测定,《福建省药品标准汇编》(1980年)中采用高氯酸非水滴定法,此法操作繁琐费时,且因消耗量少,滴定终点不易掌握而影响结果。为此,我们试用分光光度法测定TMP的含量,结果尚属满意。 1.实验方法:精密吸取本品10ml(约相当于C_(14)H_(18)O_3N_40.1g),置125ml分液漏斗中,加氨试液6ml,振摇待有白色沉淀析出后,加
Compound gentamicin needle is gentamicin sulfate and trimethoprim (TMP) complex preparation. Prescription: Gentamicin sulfate 15 million units, TMP 109, anhydrous sodium sulfite 2g, propylene glycol 300ml, water for injection, the full amount made of 1000m1. The injection of TMP content determination, “Fujian Pharmaceutical Standards Compilation” (1980) using perchloric acid non-aqueous titration, this method is cumbersome and time-consuming operation, and because of less consumption, titration endpoint is not easy to grasp and affect the results. To this end, we try spectrophotometric determination of TMP content, the results are still satisfactory. 1. Experimental Methods: Precision drawing this product 10ml (equivalent to about C_ (14) H_ (18) O_3N_40.1g), set 125ml separatory funnel, add ammonia solution 6ml, shake to be precipitated white precipitate, plus