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血药浓度监测(Therapeutic Drug Monitoring,简称TDM)是近十多年发展起来的边缘学科,主要是分析测定血浆或其他体液(如尿、唾液)中药物的浓度,其任务是提高药物治疗效果,确保用药安全。一、TDM如何指导合理用药血药浓度与药物的药理效应有着密切的关系,因为药物的吸收、分布、代谢、排泄疗效、毒副反应和血浆茶碱浓度有明显的关系,血浆茶碱浓度达5mg/L,有一定治疗作用,10～20mg/L是较合适的治疗浓度,超过20mg/L则中毒反应逐渐增多。苯妥英钠抗癫痫与抗心律失常的安全有效的血药浓
Therapeutic Drug Monitoring (TDR) is a marginal subject developed in recent ten years. Its main task is to analyze and measure the concentration of drugs in plasma or other body fluids (such as urine and saliva), and its mission is to improve the therapeutic effect of drugs, Ensure medication safety. First, TDM how to guide the rational use of drug blood concentration and drug pharmacological effects are closely related, because the drug absorption, distribution, metabolism, excretion efficacy, toxicity and plasma theophylline concentration have a clear relationship, plasma theophylline concentration of up to 5mg / L, a certain therapeutic effect, 10 ~ 20mg / L is more appropriate treatment concentration, more than 20mg / L poisoning reaction gradually increased. Phenytoin sodium Anti-epilepsy and anti-arrhythmia safe and effective blood concentration