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筛选镇咳药物时,氨水是常用的引咳剂,但氨气的释出速度易受环境温度的影响,故其浓度即刺激强度常很难精确控制。一般认为,实验应于相对恒温室内进行[医科院药物所;中草药有效成分的研究,第二分册,73页,人民卫生出版社,1972],或用纯氨气代替氨水引咳[J Phar-macol Expt Therap,112:99,1954;116:296,1956]。这些均要求一定设备,非一般实验室易于设置。为了克服此缺点,我们利用沸水的相对高温(100℃),使氨水迅速释出其所含全部氨气,从而消除了环境温度的影响。实践表明,无论在盛夏(室温30℃以上)或寒冬(生火后室温10℃左右),同量氨水的引咳效果基本恒定。兹介绍如下。
Ammonia is a commonly used cough suppressant when it comes to screening antitussives, but the release rate of ammonia is easily affected by the ambient temperature, so the concentration, which is the stimulus intensity, is often difficult to precisely control. Generally believed that the experiment should be carried out in a relatively constant temperature chamber [Institute of Materia Medica; Chinese herbal medicine active ingredient research, the second volume, 73 pages, People’s Health Publishing House, 1972], or pure ammonia instead of ammonia cough [J Phar- macol Expt Therap, 112: 99, 1954; 116: 296, 1956]. These require certain equipment, non-general laboratory easy to set. In order to overcome this shortcoming, we use the relatively high temperature of boiling water (100 ℃) to release all the ammonia contained in ammonia quickly, thus eliminating the influence of ambient temperature. Practice shows that both in the summer (room temperature above 30 ℃) or winter (after firing at room temperature around 10 ℃), with the same amount of ammonia water cough effect is basically constant. Here is the introduction.