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纳米凝胶具有粒径小、血液循环时间长、生物相容性好、生物可降解、载药量高等优点。通常用于制备纳米凝胶的载体材料有聚丙烯酸及聚丙烯酰胺类、普朗尼克类、聚多糖类高分子材料及其衍生物,可通过基于氨基的交联、“click”反应交联、物理交联、光交联、多相单体聚合等方法形成纳米凝胶。纳米凝胶作为一种理想的新型给药系统在化疗药物、蛋白类药物及基因的递送等方面显示出广阔的应用前景。笔者参考近期相关文献,对纳米凝胶的常用载体材料,制备方法及应用进行整理与总结。
Nano-gel has the advantages of small particle size, long blood circulation time, good biocompatibility, biodegradability and high drug loading capacity. Common carrier materials for the preparation of nanogels include polyacrylic acid and polyacrylamides, pluronics, polysaccharide polymers and their derivatives, which can be synthesized by amino-based crosslinking, “click” reaction Crosslinking, physical crosslinking, photocrosslinking, polymerization of heterogeneous monomers and the like. Nano-gel as an ideal new drug delivery system in the chemotherapy drugs, protein drugs and gene delivery has shown a broad application prospects. With reference to recent relevant literature, the author summarizes the commonly used nano-gel carrier materials, preparation methods and applications.