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近年来对治疗肺结核病进行了大量的短程化疗方案的研究,综述如下: 一、短程化疗的理论基础 Mitchison提示在一个菌群中,可能包括四组不同代谢状态的结核菌,它们对化疗的反应亦不相同。第一组代谢旺盛、持续繁殖的结核菌,大多数有效的抗结核药物均能迅速将其杀灭。第二组大部分时间处于代谢不活跃或休眠状态的结核菌,但可发生短期生长繁殖,只有杀菌作用迅速的药物利福平能将其杀灭。第三组处于细胞内结核菌,由
In recent years, a large number of short-course chemotherapy for pulmonary tuberculosis treatment program, summarized as follows: A theoretical basis of short-course chemotherapy Mitchison suggested that in a flora, may include four different metabolic states of Mycobacterium tuberculosis, their response to chemotherapy Not the same. The first group of metabolically active, sustained-reproducing Mycobacterium tuberculosis, most effective anti-TB drugs can kill it quickly. The second group, most of the time, is in a metabolically inactive or dormant state of Mycobacterium, but short-term growth and reproduction can occur and only the rapidly acting bactericidal rifampicin can kill it. The third group is intracellular TB, from