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目的探讨CO2气腹对肝硬化兔肝功能及血清一氧化氮NO的影响及可能机制。方法制作兔肝硬化模型,闭合法建立气腹,分别于术中不同压力和术前、术后不同时间采取静脉血检测血清ALT,AST及NO的含量。结果常规气腹压(11mmHg)下正常兔血清ALT,AST及NO含量气腹术后一定时间内较气腹前轻度增高,7d基本恢复。肝硬化兔血清ALT,AST气腹后增高明显,7d不能恢复正常,NO气腹前后始终无明显变化。结论肝硬变条件下,一定的CO2气腹压力对肝功能的损害较大,血清NO反应不敏感,不能反应性增高。
Objective To investigate the effects of CO2 pneumoperitoneum on hepatic function and serum level of nitric oxide in cirrhosis rabbits and its possible mechanism. Methods Rabbit liver cirrhosis model was established. The pneumoperitoneum was established by closed method. Serum ALT, AST and NO were detected by venous blood at different pressures and preoperatively and postoperatively respectively. Results The serum ALT, AST and NO levels of normal rabbits under conventional pneumo-abdominal pressure (11mmHg) were slightly higher than those before pneumoperitoneum within a certain time after pneumoperitoneum, and recovered after 7 days. Liver cirrhosis serum ALT, AST increased significantly after pneumoperitoneum, 7d can not return to normal, NO pneumoperitoneum before and after no significant change. Conclusions Under the condition of cirrhosis, a certain CO2 pneumoperitoneum pressure has a greater damage to liver function, and the serum NO response is not sensitive and can not be increased.