经皮经导管射频消融去肾交感神经术(sympathetic renal denervation,SRD)可作为药物控制不佳的难治性高血压患者的一种替代治疗方法,SRD对减少短期血压变异性(blood pressure variability,BPV)有效。然而,这个作用尚未在随机对照试验中证实。本研究旨在比较螺内酯和SRD对昼夜血压和BPV的影响。方法:对一项随机试验进行析因分析,比较确诊 Percutaneous transcatheter radiofrequency ablation of sympathetic renal denervation (SRD) can be used as an alternative treatment for refractory hypertensive patients with poorly controlled drugs. SRD can reduce the short-term blood pressure variability BPV) is valid. However, this role has not been confirmed in randomized controlled trials. The aim of this study was to compare the effects of spironolactone and SRD on diurnal blood pressure and BPV. Methods: A randomized trial of factorial analysis, more confirmed