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本文旨在研究亚胺硫霉素与青霉素结合蛋白(PBPs)结合后的形态学及超结构改变之间的关系;评价本品对绿脓杆菌的杀菌动力学及对大肠杆菌和金葡菌的杀菌动力学进行比较.结果显示,最低抑菌浓度(MIC),1/2 MIC,1/4 MIC和1/8 MIC的亚胺硫霉素与受试细菌接触24h后光学显微镜下均可见形态异常的细胞.1/2 MIC的本品与绿脓杆菌接触1h后,形态发生明显改变,出现与细胞长轴垂直方向的突出结构,接触2h后,这种突出仍在持续,甚至变成卵圆形,细胞质模糊不清.然而在此期后,一些细菌能保持其细菌形态学,并开始出现溶解现象.接触3h后,细菌的一端突出使
This article aims to study the relationship between the morphological and ultrastructural changes of the binding of imipenem to penicillin-binding proteins (PBPs); to evaluate the bactericidal kinetics of this product against Pseudomonas aeruginosa and its effect on E. coli and S. aureus Bactericidal kinetics were compared.The results showed that the lowest inhibitory concentration (MIC), 1/2 MIC, 1/4 MIC and 1/8 MIC of thimolimus and bacteria exposed to the test after 24 hours under a light microscope morphology Abnormal cells .1 / 2 MIC of this product and Pseudomonas aeruginosa contact 1h, the morphological changes significantly, with the long axis of the cell prominent structure, contact 2h, this protrusion is still continuing, and even become eggs Round, the cytoplasm was blurred, however some bacteria kept their bacterial morphology and began to dissolve after this period.After exposure for 3h, one end of the bacterium protruded