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肝淋巴上皮瘤样癌(LELC)是一种罕见的肝癌亚型,具有独特的流行病学、病理学特征,特点是大量的淋巴细胞浸润,可分为淋巴上皮瘤样肝细胞癌(LEL-HCC)和淋巴上皮瘤样肝内胆管细胞癌(LEL-CC),其诊断主要依靠病理学方法,治疗以手术为主。肝LELC预后良好,可能与大量淋巴细胞浸润有关。关于LELC的资料非常有限,仅有少量的病例报道和小型回顾性研究,还需要进一步深入研究。截至目前,已有67例LEL-HCC和34例LEL-CC在文献中报道。文章总结了肝LELC的流行病学、临床治疗、病理学特点以及研究前景。“,”Lymphoepithelioma-like hepatic carcinoma (LELC) is a rare distinctive variant of liver cancer with unique epidemiological and pathological characteristics, characterized by dense lymphocyte infiltration.It can be divided into lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) and lymphoepithelioma-like cholangiocarcinoma (LEL-CC). The diagnosis is mainly based on pathology, and the treatment is mainly surgery. The prognosis of LELC is good, which may be related to a large number of lymphocyte infiltration. The data of LELC is very limited, only a few case reports and small retrospective studies, which needs further exploration and research. Up to now, 67 cases of LEL-HCC and 34 cases of LEL-CC have been reported. The purpose of this review is to provide a comprehensive overview of the current research situation on LELC in terms of epidemiology, clinical treatment, pathology and research prospects.