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目的 :观察苯乙酸钠 (NaPA)对家兔创伤愈合的作用。方法 :用 2 4只大耳白家兔制作背部创伤模型 ,随机分为静脉用药、局部用药与对照 3组 ,每组 8只 ,实验观察至创伤后 2 1d。结果 :两用药组于创伤后第 6天起 ,创面明显比对照组缩小 (P <0 .0 5 ) ;创伤后第 15天起两用药组愈合率也明显比对照组高 (P <0 .0 5 ) ;创伤后不同时间 3组家兔纤维结合蛋白水平 (fibronectin ,Fn)组间比较无差异。结论 :苯乙酸钠静脉或局部给药对创伤愈合均有促进作用 ,创面愈合与纤维结合蛋白的关系不明显
Objective: To observe the effect of sodium phenylacetate (NaPA) on wound healing in rabbits. Methods: Dorsally trauma models were made in 24 rabbits with white rabbits, and were randomly divided into three groups: intravenous drug, topical drug and control group, with 8 rats in each group. The rats were observed 21 days after trauma. Results: On the 6th day after trauma, wounds of the two groups were significantly smaller than those of the control group (P <0.05). The healing rate of the two groups was also significantly higher than that of the control group on the 15th day after trauma (P <0. There was no difference in fibronectin (Fn) between the three groups at different time points after trauma. Conclusion: Intravenous or topical administration of sodium phenylacetate can promote wound healing, and the relationship between wound healing and fibronectin is insignificant