在一级速率过程的一室开放模型中,单用血药浓度数据测定吸收速率常数(ka)和消除速率常数(ke)的方法依赖于两者之差的大小。在 kake 的情况下,可将 logCb 对 t 作图,从末端直线相的斜率求得 ke(Cb 为体内药物浓度,t 为时间);用剩余法求得 ka。同样,当 kea[即所谓触发 In a one-compartment open model of the first-order rate process, the method of determining the absorption rate constant (ka) and the elimination rate constant (ke) using the plasma concentration data alone depends on the magnitude of the difference between the two. In the case of kake, logCb can be plotted against t, and ke can be obtained from the slope of the end linear phase (Cb is the in vivo drug concentration and t is the time); Similarly, when kea [the so-called trigger