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阿霉素被认为是对肝癌有效的化疗药物之一。但各家报告有效率悬殊。为探讨阿霉素治疗肝癌的疗效给药方案的关系,我们分别用每周小剂量、间歇大剂量或每周小剂量联合化疗三组进行临床观察。 住院的原发性肝癌病人,其中部分为经剖腹探查不能切除者,共计40例,男36例,女4例。年龄16～60岁,其中30～50岁占30例(75％),平均年龄41.0岁。按1977年上海全国肝癌研究协作会制定的诊断分型标准,单纯型Ⅱ期20例,Ⅲ期6例,硬化型Ⅱ期7例、Ⅲ期7例。AFP阳性29例。获病理诊断有25例,均为肝细胞肝癌,AFP阴性的11例中有9例获病理
Adriamycin is considered to be one of the effective chemotherapy drugs for liver cancer. However, the efficiency of the reports varied widely. In order to investigate the relationship between doxorubicin treatment of hepatocellular carcinoma and the efficacy of dosing regimens, we used weekly low-dose, intermittent high-dose or weekly low-dose combination chemotherapy for clinical observation. Among the hospitalized primary liver cancer patients, some of them were unresectable by laparotomy. A total of 40 patients were included, including 36 males and 4 females. 16 to 60 years old, 30 to 50 years old accounted for 30 cases (75%), the average age of 41.0 years. According to the diagnostic typing criteria developed by the Shanghai National Hepatic Cancer Research Association in 1977, there were 20 cases of simple type II, 6 cases of stage III, 7 cases of stage II sclerosis, and 7 cases of stage III. AFP positive in 29 cases. Twenty-five patients were pathologically diagnosed with hepatocellular carcinoma, and 9 of 11 patients with AFP negative were pathological