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目的:评价生肌白玉膏对大鼠深Ⅱ度烫伤创面肉芽组织中表皮生长因子(EGF)和血管内皮生长因子(VEGF)的影响。方法:80只深Ⅱ度烫伤大鼠随机分为生肌白玉膏组、美宝湿润烧伤组,生理盐水组和空白组,在第3、7、14、21天用免疫组化方法测定创面肉芽组织中EGF、VEGF阳性细胞变化。结果:实验组大鼠创面肉芽组织中EGF和VEGF阳性表达明显高于其他组(P<0.01)。结论:生肌白玉膏可能通过影响EGF和VEGF促进创面愈合。
Objective: To evaluate the effects of Shengji Baizu Ointment on epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) in granulation tissue of rats with deep second degree scald wounds. Methods: Eighty deep second-degree scald rats were randomly divided into Shengji white ointment group, MEBO moist burn group, normal saline group and blank group. On the 3rd, 7th, 14th and 21st day, the wound granulation was determined by immunohistochemistry The changes of EGF and VEGF positive cells in the tissue. Results: The expression of EGF and VEGF in wound granulation tissue in experimental group was significantly higher than that in other groups (P <0.01). Conclusion: Shengji Baiyu Paste may promote wound healing by affecting EGF and VEGF.