壬苯聚醇-9是一种非离子化清洁剂,作为杀精剂应用已有50余年历史,在体外可杀灭许多病原体,例如淋球菌、沙眼衣原体、杜克雷嗜血杆菌、梅毒螺旋体、阴道毛滴虫与单纯疱疹病毒。体外与动物试验表明,阴道内使用壬苯聚醇-9可保护妇女免受HIV感染与STIs。本研究旨在比较壬苯聚醇-9凝胶加避孕套(凝胶组)与单用避孕套(避孕套组)预防泌尿生殖道淋球菌与衣原体感染的性传播作用。 Nonoxynol-9 is a non-ionizing detergent that has been used for more than 50 years as a spermicide and can kill many pathogens in vitro, such as Neisseria gonorrhoeae, Chlamydia trachomatis, Haemophilus ducreyi, Treponema pallidum, Trichomonas and herpes simplex virus. In vitro and animal studies have shown that intravaginal use of non-Benzene-9 can protect women from HIV infection with STIs. The aim of this study was to compare the sexual transmission of urogenital gonococcal and chlamydial infections with the non-Benzene-9 gel plus condoms (gel group) and the condom alone (condom group).